Pain receptor regulates lifespan and metabolic health in mice and may have an impact on the man

Pain receptor regulates lifespan and metabolic health in mice and may have an impact on the man

Chronic pain in humans is associated with worse health and a shorter life span, but the molecular mechanisms underlying these clinical observations are not clear. A study published by cell press in the journal cell show that the activity of a pain receptor called TRPV1 longevity and metabolic health in mice. The study suggests that the aging process can affect pain perception and reveals new strategies that could improve metabolic health and longevity in humans.

"The TRPV1 receptor is a great drug target with many well-known drugs in the clinic that can impact function," says senior study author Andrew Deer of the University of California, Berkeley. "Find that manipulation of this receptor can not only to promote a youthful metabolism but also increase service life must be very important for age-related diseases, diabetes is a big problem."

Past research has shown that mice lacking TRPV1 are protected from diet-induced obesity, suggest that this receptor plays a role in the metabolism. Diets rich in capsaicin – the active molecule of chili peppers which can overstimulate and kill TRPV1 neurons-are intriguing, long linked to lower incidents of diabetes and metabolic problems in humans. In addition, distortion of sense perception increases the life span in worms and flies. But so far, it was not known whether sensory perception, also affects aging in mammals.

Addressing this issue in the new study, found that mice Deer and his team genetically manipulated to lack of TRPV1 receptors on average almost four months, or approximately 14%, more than normal mice lived. The TRPV1-deficient mice also showed signs of a youthful metabolism late in life, as a result of low levels of calcitonin gene-related peptide (CGRP)-a molecule that raises the blood glucose levels and thus can contribute to the development of type 2 diabetes. Throughout the aging showed these mice improved glucose tolerance-the ability to quickly clear sugar from the blood, as well as the signs that they can burn more calories without exercising more than usual.

In addition, old mice treated with a substance that the activity of CGRP receptors showed a more youthful metabolic profile than untreated old mice inhibits. "Our findings suggest that pharmacological manipulation of TRPV1 and CGRP can improve metabolic health and longevity," says Deer. "As an alternative, chronic intake of substances that affect TRPV1 like capsaicin can help prevent the decrease in metabolic with age and lead to an increased life expectancy in humans."

Cell, Riera et al.: "TRPV1 pain receptors regulate life span and metabolism by neuropeptide signaling."

Cell press

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