Patients with some form of kidney disease may have a reduced risk of cancer compared to patients with other kidney diseases, according to a study appearing in an upcoming issue of the journal of the American Society of Nephrology (JASN).
Polycystic kidney disease (PKD) is a disorder of the kidney by given by families in which many form of cysts in the kidneys, causing them to be extended. It has thought to have cancer-like properties, but cancer risk has never been compared between PKD patients and others with kidney disease. Cancer risk is also increased in people who have received a kidney transplant, due to the Immunosuppressive medications they should take.
James b. Wetmore, MD, MS (University of Kansas Medical Center) and his colleagues, the first study cancer risk in kidney transplant recipients with PKD research and compare their risk for those of other kidney-transplant recipients.
The team analyzed data from the National Cancer Institute Cancer transplant Match study, which information on all solid organ transplant recipients in the United States, as well as population-based data from 15 American Cancer Registries. For PKD receivers, the researchers compared to overall cancer risk to those in the general population. They also compared cancer cases in PKD versus non-PKD kidney-transplant recipients. The analysis included 10,166 kidney-transplant recipients with PKD and 107,339 without it.
After adjusting for demographic differences between kidney recipients with PKD PKD patients and other recipients, were 16% less chance of developing cancer than others who received a kidney transplant. Compared with the general population, was total cancer risk increased by 48% in PKD receivers, while overall cancer risk in non-PKD recipients increased 86%.
The findings indicate that PKD patients who receive transplants not a higher risk of cancer than other kidney-recipients. In fact, their risk of cancer may be lower. "The reason for the reduced risk is uncertain, but some factor or factors in PKD patients-either inherent to the disease process itself or in connection with the care patients receive PKD-is associated with lower risks of cancer," said Dr. Wetmore. "Further study is required to determine how PKD can affect cancer development."
Dr. Wetmore speculated that PKD certain anti-neoplastic defense mechanisms that provide protection against the development of cancer can cause. Alternatively, it may be that PKD patients, who often aware that they have a progressive condition and who are therefore usually receive close medical care for many years or decades, participate in other healthy behaviors that prevent cancer.
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